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WalletHub compared the relative start-up opportunities that exist in 100 large U.S. cities across three key dimensions: 1) Business Environment, 2) Access to Resources and 3) Business Costs. Since one in every five startups doesn’t make it past the first year, it’s important for new business owners to live in a city where start-ups can succeed. Using 19 key metrics, including the five-year business-survival rate, labor costs and office-space affordability, Phoenix metro area cities came out on top. The Valley of the Sun cities in the top 25 are: #1 Chandler, #8 Glendale, #14 Scottsdale, #20 Mesa, #21 Phoenix, and #24 Gilbert. What cities were the most unfriendly to a new enterprise? New York was #96, Fremont, CA #97, Honolulu, HI #98, San Jose, CA #99, and dead last at #100 was Washington, DC.